Academia: BSc – Physics, Université Laval
Advisors: Daniel Côté, Yves DeKoninck
Research interests: In vivo imaging, Blood-brain barrier disruption, Multiple sclerosis/EAE
Multiple sclerosis (MS) is a chronic disease that causes inflammation and demyelination of the central nervous system. The lesions are the result of a high number of immune cells, leukocytes, that crossed the blood-brain barrier (BBB) to get into the central nervous system. To develop better therapies, it is essential to understand the early stages of the infiltration, in particular the proteins and molecular events involved in the blood-brain barrier disruption.
We use optical microscopy (2-photon) to image in vivo the blood-brain barrier breakdown in the MS animal model experimental autoimmune encephalomyelitis (EAE). Using different permeability markers, we study the progression of the disease and correlate it to the BBB disruption, cellular infiltration and demyelination.